Professor Jesús A F Tresguerres
Dept of Physiology Medical School University Complutense Madrid Spain. Professor Tresguerres is an endocinologist. He has worked on growth and the aging processes, participated in the discovery of important basic information about short-term growth (within days) and the influence of glutamate on the satiation regulation in the brain.
2016 - Therapeutic Effects of High Dose Chronic Melatonin Administration
The effect of high dose melatonin administration on several diseases are reviewed.
Experimental studies performed over more than 20 years have shown that oxidative stress
and inflammation increase in nearly all tissues with many degenerative diseases or aging. We
have measured several parameters related to oxidative stress, inflammation and apoptosis both
in several models of aging and also after isquemia in liver or brain. The effect of treatment
with melatonin has been evaluated showing a significant reduction of inflammation markers
(tumor necrosis factor-alpha, interleukin 1 and 10, NFkBp50 and NFkBp52), apoptosis
markers (BAD, BAX and Bcl2) and parameters related to oxidative stress (heme oxygenases
1 and 2, endothelial and inducible nitric oxide synthases) in several tissues . Inflammations, as
well as, oxidative stress and apoptosis markers were increased also in degenerative diseases
like diabetes ,hypertension or Parkinson disease so treatment with melatonin should also have
very positive effects...
When the skin is submitted to ionizing radiation like radiotherapy a marked release of free
radicals inducing inflammation and oxidative stress is obtained giving rise to radiodermitis
All the above mentioned parameters have been also shown to be increased in the skin. .
Melatonin treatment was able to reduce those markers and oxidative stress preventing the
appearance of radiodermitis .
CONCLUSION: Melatonin administrations exerts beneficial effects against age- or
degenerative diseases induced changes in several tissues and functions.