Roger Deutsch has performed pioneering research in the field of food and chemical sensitivity testing for over 22 years. He is a co-developer of the Alcat test, a unique, patented method for identifying cellular reactions to foods, chemicals and other substances, through non-IgE mediated pathways. The Alcat test is a proprietary blood test performed in many laboratories and clinics throughout the world. He is co-author of the book series, Your Hidden food Allergies are Making You Fat, as well as several review and research papers on this topic. He frequently lectures on the subject of food, inflammation and aging to professional audience’s world wide. Roger serves as the CEO of Cell Science Systems, Ltd., Corp. (Deerfield Beach Florida). Cell Science Systems is an integrated medical diagnostics and health care company on the cutting edge in the field of food intolerance diagnostics and management. He is also the CEO of Alcat Europe (GmbH, Berlin, Germany).
2008 - Food, inflammation, and the aging process
The chemical composition of foods can, by virtue of activation of various receptors, such as PPAR receptors and STAMP 2 (six transmembrane protein of prostate – 2) activate either inflammatory or anti-inflammatory pathways in cells. Activation of the former leads to the generation of toxic mediators and free radicals. Oxidative stress has been liked to many degenerative diseases of aging including cardiovascular disease, dementia and insulin resistance; as well as inflammatory and auto-immune processes, such as asthma, RA (rheumatoid arthritis) urticaria, and inflammatory bowel diseases. Upregulation of the inflammatory process further promotes aging by increasing cortisol levels, to the suppression of sex hormones, and the shortening of telemeres.
Attempts have made to devise methods to determine the individual food intolerances or sensitivities that, in part, underlie these processes. The problem in testing is that there is no single clear-cut biological pathway underlying such reactivity as exists in the Gell and Combs type I reactivity that mediates “true” food allergy. Further, gene nutrient interaction studies thus far have shown little or no clinical value in determination of individualized dietary recommendations as the constituents in foods are too numerous and epigenetic phenomena render single gene nutrient interaction analysis limited and confused.
Moreover, several pathogenic mechanisms, both immune and non-immune, are involved in delayed reactions to foods. Hence, a non-mechanism dependant approach that can indicates a final common pathway, associated with the initiation and perpetuation of the inflammatory response, is desirable. The effects of the modern diet, the mechanisms underlying the inflammatory pathways so activated by dietary and lifestyle factors, the extant methods of testing food intolerance, as distinct from food allergy, with highlighting of a new cellular approach (the Alcat test) that is not mechanism dependent, and the advantages of such testing in the anti ageing clinical setting, will be reviewed.