Dato Harnam MD PhD
President, Society of Anti-Aging Medicine
Graduated from University of Malaya (now known as University
of Singapore) – MBBS, passed biochemistry with distinction and
was the second student in the pre-clinical examination - awarded Bronze
Awarded Government Scholarship to do Post-Graduate
studies in United Kingdom. Registrar, Warwick Hospital and the Royal
National Ear, Nose and Throat/Head and Neck Hospital, Gray Inn Road,
He worked as Consultant Otolaryngologist
– General Hospital, Johor Bahru, Malaysia – set up the Ear,
Nose and Throat Centre and subsequently appointed Senior Ear, Nose and
Throat Consultant, Hospital Kuala Lumpur until 1969. Later set up his
own Ear, Nose and Throat Centre at Jalan Ipoh, Kuala Lumpur, where he
is currently practising as an Otolaryngologist. He has special interest
in Allergy and Anti-Aging.
Cellular and and Molecular
Basis of Aging
Once we graduate, doctors tend to forget what we
learnt about the basic physiology of how the body functions, especially
the Krebs cycle, which is the engine that drives the human body. This
failing metabolic function is the single most important risk factor
that causes disease, disability and death. The free radicals produced
during cellular metabolism cause damage to the mitochondria and cells.
The body's functions are regulated by a
network of hormonal cascades that are produced by the various organs
with the pituitary being the leader and the central server. Diet, exercise,
xenobiotics and lifestyle also play a vital role.
When the body's metabolism is in balance
and regulated, we stay healthy. However, the anabolic hormones begin
to decline after the age of 35. The body then experiences a progressive
degeneration. At the same time, the catabolic hormones, e.g. cortisol,
increase leading to progressive shift towards increasing catabolism
For the Krebs cycle and mitochondrial metabolism
to be facilitated, the mithochondria need biological catalysts in the
form of nutraceuticals / vitamins. Without the regular and optimal supply
of these bio-energy sources, there is functional deficiency, organ malfunction,
mithocondrial, DNA and cellular damage, which trigger degenerative diseases,
aging and death.
For a healthy lifestyle it is vital that
we understand the cellular biology and physiology in order to stay healthy,
prevent degenerative diseases, aging and death.