Suresh Rattan PhD DSc
Laboratory of Cellular Ageing, Danish Centre
for Molecular Gerontology, Department of Molecular Biology, University
of Aarhus, Denmark.
Dr. scient. (D.Sc.) 1995, University of Aarhus, Denmark.
Ph.D. 1982, National Institute for Medical Research, Mill Hill, London,
M.Phil.1979, Jawaharlal Nehru University, New Delhi, India.
M.Sc. 1977, Guru Nanak Dev University, Amritsar, India.
Research areas and expertise
Ageing (biogerontology, molecular gerontology); Anti-ageing; Stress
response and hormesis. Committed to research, guidance, communication,
consultancy and advice on ageing intervention, prevention and therapies.
Causes of Ageing,
Age-Related Diseases and Principles of Anti-Ageing
Scientific approaches to ageing intervention,
prevention and therapy are based on knowledge gained through more than
fifty years of research in biogerontology. The phenomenon of ageing
has been well described at the level of species, individuals, organs,
tissues, cells and molecules. Biologically, ageing is considered to
occur during the survival period which is beyond the naturally required
essential lifespan. Most importantly, there are no specific genes for
ageing – gerontogenes – and ageing occurs mainly due to
the progressive failure of maintenance and repair pathways. Such changes
in defence mechanisms lead to an overall impairment of the physiological
functions throughout the body, and result in the appearance of one or
more of age-related dysfunctions and diseases. An absence of gerontogenes
makes it possible to slow down ageing and to achieve a healthy old age
by life style modulations. Antioxidants, hormones and other nutritional
supplements are used to modulate ageing. However, there is a lot to
understand about the mode of action of such treatments in order to make
best use of them. Recently, highly effective small molecules such as
kinetin, zeatin, resveratrol and others have been discovered which have
a range of beneficial health protecting effects.. Collectively, such
molecules can be termed as “protectins”, which protect the
cells and organisms from age-related accumulation of molecular damage.
Another approach in ageing prevention is that of hormesis, which refers
to the beneficial effects of mild stress - physical, chemical, biological
and mental. Application of hormesis in ageing research and therapies
holds a significant promise. Although immortality and eternal youth
may never be possible, achieving a healthy old age without major diseases
is now a real possibility based on scientific principles.
Objectives of the presentation:
1. To give an overview of the state-of-art information about the biological
basis of ageing and age-related diseases in various anatomic parts of
2. To critically evaluate various anti-ageing approaches which either
are already in practice or are in research and development.