Fritz H. Bach MD
Dr. Fritz Bach, born in Vienna, Austria, attended
Harvard College and Harvard Medical School, took an internal medicine
residency, and since 1963 has done research at the University of Wisconsin,
Madison, the University of Minnesota, Minneapolis and now Harvard Medical
School in Boston. He has worked in genetics, immunology and recently
vascular biology, with much of his work devoted to studies of transplantation.
He described the mixed leukocyte culture (MLC) test for matching donors
and recipients for transplantation, which led to his contributing to
the description of the major histocompatibility complex (MHC) in humans
(HLA), heading the team that did the first successful matched bone marrow
transplant, defining the existence of class II loci and their antigens
and establishing the existence of two types of antigens with different
functions associated with the MHC.
His work in xenotransplantation included
his suggestion that endothelial cell activation is the key role in xenograft
rejection and, with his colleague Augustin Dalmasso, to suggest that
transgenic pigs expressing a human gene to block human complement may
help solve xenograft rejection. As a part of the progress in xenotransplantation,
he suggested that endothelial cells might express protective genes that
help to avoid rejection, which he and his colleagues have not shown
to be true.
Dr. Bach has received numerous awards,
including Peter Medawar Prize of the International Transplantation Society
and the most recent which is the Doctor of Medicine, Honoris Causa,
2005 from the University of Vienna.
The Body's Molecules Provide
their own Best Protection Against Ageing
Heme oxygenase?1 (HO?1) breaks down heme
to yield carbon monoxide (CO) and
biliverdin/bilirubin, two molecules that have been viewed as toxic.
suggests that CO and bilirubin can be beneficial in humans. Individuals
who have high
normal levels of bilirubin have less atherosclerotic events as compared
individuals with low normal bilirubin. The HO?1 system may well act
to prevent tissue
aging by the protective functions of the products of heme degradation.
Goals and Objectives: