Professor George Birkmayer MD PhD
Ph.D. in Biochemistry, University of Vienna, Austria
M.D. from the University of Munich,.
Since 1982 Professor for Medical Chemistry, University of Graz, Austria.
Guest Lecturer at Universities in New York, Philadelphia, Montreal
Since 1989 visiting Professor at the Universities of Beijing, Guangzhou and Xi’An (China). He is a Fellow of the American College of Nutrition and a number of international societies.Since 2005 President of the Int. Academy of Tumour Marker Oncology (IATMO), New York. Honorary President of the International Academy of Tumor Target Therapy Guangzhou Senior Medical Advisor of Food and Agriculture Security Committee Affiliated to S.A.V.E.

2011 - NADH (Coenzyme 1): Newest findings on its Anti-Diabetic, Anti-Obesity, Anti-Skin Aging and Ati-Fatigue Effect

Coenzyme-1 (N.A.D.H.) is one of the most important coenzyme catalyzing more than a thousand of metabolic reactions in the human body, the most important of which is the production of ATP (Adenosin-Tri-Phosphate) The more ATP energy a cell has available the better it can function and the longer it can live. The question is can we increase the ATP production in the cells by exposing them to coenzyme-1 (NADH). The answer is yes, we can, as has been shown on isolated heart cells. When hearts cells are incubated with NADH a 30% increase in ATP production is observed (1). Due to this the vitality and lifespan of these heart cells are increased.
This heart cell system allows to test other coenzymes and substances for which an energy increasing effect has been claimed. From all the substances tested so far including NAD (the oxidized form of NADH), Nicotinamide (Vitamine B3), Coenzyme Q10, Creatine, Carnitine , Caffeine only NADH does increase ATP production in these cells. NADH as biological form of hydrogen is a very sensitive substance which degrades rapidly even in dry state when blended with lactose the most common ingredient of drugs. The author succeeded in stabilizing NADH and transposing it into a tablet form in which NADH is stable for at least 2 years. This formulation, patented world-wide is commercially available under the brand name CELLERGIE™ NADH.
Based on the patent protection of this product numerous GCP studies have been performed in the U.S. as well as in Europe. In an FDA approved double-blind placebo controlled study it was found that NADH leads to an improvement of certain cognitive functions in patients with Alzheimer dementia. (2) . Another FDA approved double blind study with patients suffering from CFS (Chronic Fatigue Syndrome) revealed more than 80 % of the patients were relieved from their fatigue after a 6 month treatment period with 10 mg NADH per day(2).A retrospective analysis of the change in bodyweight of the CFS patients showed a decrease of 5.5 lbs per month with a daily dose of 10 mg NADH. In a further open label trial obese subjects (BMI > 30) were taking 40 mg NADH per day over 3 months. The reduction in weight was in the range of 4.5 to 6.0 kg in between the 3 month trial period. All subjects observed a higher energy level and better physical performance after 1 month. In a further study patients suffering from Diabetes Typ-2 were taking 80 mg NADH per day for 3 months. The average HbA1c value of these subjects were in the range of 13.0 – 15.3. After a 3 months treatment period the HbA1c levels declined to 6.8 – 8.5. All the patients could omit their antidiabetic medications after the 3 months therapy with NADH. The author developed a skin serum on the basis of NADH. A study performed at the department of dermatology of the university of Freiburg (Germany) showed an remarkable anti-wrinkle effect . Aging spots on the palm back disappeared after a 3 months treatment period.
Furthermore the effect of NADH on cognitive performance was tested with healthy middle aged individuals after sleep deprivation for 24 hours at Cornell University(New York) Subjects taking 20 mg of NADH did not only better than the subjects taking placebo but did more than 3 times better than the same subjects at base line, after a full night sleep (4). In other words, NADH enhances cognitive performance in healthy individuals and due to its energy-increasing effect for the brain it may prevent MCI (Mild Cognitive Impairment) as well as Alzheimer dementia. of NADH.(3) The mechanism of action of NADH is based in all the studies described on the elevation of the intracellular ATP. A detailed description of all potential therapeutic applications of NADH is compiled in my book “NADH – the biological hydrogen- the secret of our life energy (4).

References:
(1) Pelzmann, B., et al., Brit.J.Pharm.2003, 139, 749-754
(2) ) Forsyth, L.M., et al. Ann.Allergy Asthma Immun. 1999, 82, 185-191
(3) Moline, ML. Et al. Abstr.1st Int. Conf. Mech. Action Nutraceuticals 2001
(4) Birkmayer G., Basic Health Publications Inc. CA 92651 (2009) ISBN 978-1-59120-262-2