Home | BSAAM's Organizer | BSAAM's Sponsor | London Accommodation Info | Contact Us
BSAAM's Anti Ageing Conference London 2019
Follow us on ...
Facebook  Twitter  Instagram
Conference Information
Download 2018 Feedback Form (Required for Credits)
Pre-conference Presentations
2018 Program
2018 Speaker List & Presentation Download
Speaker Videos
2018 Pre-Conference Workshops
2018 Exhibitors
2018 Peer Review Board Members
Delegate Information
2018 VENUE: The Kensington Town Hall - MAP
Nearby London Accommodations
A4M Board Certification
  American Board Of Anti-Aging/Regenerative Medicine (ABAARM)
Past Conference Information
2017 Speakers and Presentations
2017 Programme
2017 Exhibitors

BSAAMs AACL 2017 Peer Review Board Members
2016 Speakers and Presentations
2016 Programme
2016 Exhibitors
2016 Moderators
BSAAMs AACL 2016 Peer Review Board Members
2015 Speakers and Presentations
2015 Programme
2015 Exhibitors
2015 Moderators
BSAAMs AACL 2015 Peer Review Board Members
2014 Speakers and Presentations
2014 Programme
2014 Exhibitors
2014 Moderators
2014 Peer Review Board Members
2014 Aesthetic Peer Review Board Members
2013 Speakers and Presentations
2013 Programme
2013 Exhibitors
2013 Moderators
2013 Peer Review Board Members
2013 Aesthetic Peer Review Board Members
2012 Speakers and Presentations
2012 Programme
2012 Exhibitors
2012 Moderators
2012 Peer Review Board Members
2012 Aesthetic Peer Review Board Members
2011 Speakers and Presentations
2011 Programme
2011 Exhibitors
2011 Moderators
2011 Peer Review Board Members
2011 Aesthetic Peer Review Board Members
2010 Conference Manual
2010 Speakers and Presentations
2010 Programme
2010 Exhibitors
2010 Moderators
2010 Peer Review Board Members
2010 Aesthetic Peer Review Board Members
Programme for the 2009
Exhibitors for the 2009
Speakers for the 2009
2009 Peer Review Board Members
2009 Aesthetic Peer Review Board Members
Programme for 2008
Exhibitors for 2008
Speakers for 2008
2008 Peer Review Board Members
2008 Aesthetic Peer Review Board Members
  2007 Speaker List
2007 Speaker Programme
  Pre Conference Workshops
Sept 12 Pre-Conference Workshop Programme
Sept 13 Pre-Conference Workshop Programme
  2007 Peer Review Board Members
  Exhibitors for 2007
  3rd Annual Anti-Ageing Conference Manual (2006)
  Programme for 2006
  ISRM2006 Scientific Board Members
  2006 Peer Review Board Members
  Exhibitors 2006
  Post Review of 2005
  Remarks about 2005
  Peer Review Board of 2005
  Past Speakers 2005
  Past Speakers 2004
  Past Speakers Monte Carlo 2002
BSAAM's AACL Organizer
BSAAM Affiliates
AACL Supporters
HB Health
  Sun Chlorella

AACL 2013 Speaker

Professor Inderjeet Dokal

Barts and The London School of Medicine and Dentistry
Queen Mary University of London
Barts Health
London, UK

2013 - Telomeres and telomere biology in ageing

Telomeres are repetitive DNA sequences (TTAGGG) that protect chromosome ends (from cellular exonucleases and non-homologous end joining) and maintain integrity of chromosomal DNA. They serve as mitotic clocks that keep track of the number of cell divisions during a cell’s lifetime. Telomere maintenance is a complicated process and is crucially dependent on the enzyme telomerase; a complex which has two core components (TERT and TERC) and a number of co-factors (including dyskerin, NOP10 and NHP2). In normal somatic cells, such as skin fibroblasts, telomerase is not normally expressed and telomere loss occurs at each cell division. It is estimated that as much as 200 base pairs of genomic DNA is lost with each round of DNA replication. When telomeres become critically short, cells enter irreversible growth arrest state called replicative senescence or aging. In some cells (e.g. stem cells, germ cells), in which longevity is important, telomerase is expressed and telomere length is maintained.

There is considerable evidence from human studies, animal models and human disease states that telomere length could be a biomarker of biological aging. For example, patients with inherited diseases such as dyskeratosis congenita (DC) and related syndromes are characterized by having very short telomeres (due to inherited defects in telomerase, shelterin or other components of the telomere maintenance machinery) and features of premature ageing (e.g. premature greying, dental loss and early onset of cancer). Telomere length measurements, especially measurements of the shortest telomeres, provide a molecular determinant about health. It has been observed that telomere length of blood cells decreases as human’s age. Furthermore many environmental factors (such as smoking, excessive drinking) can increase the rate of telomere shortening. Telomere length measurement can therefore provide important information on an individual’s overall health.

There are several different assays for telomere length measurement; those that are able to provide information on the shortest telomeres are believed to correlate best with the ability of human cells to proliferate and replenish tissues. Telomere length measurement thus represents a useful biomarker of “biological ageing” and has potential in monitoring aspects of human health and disease.

Home | BSAAM's Organizer | BSAAM's Sponsor | London Accommodation Info | Contact Us
BSAAM's Anti Ageing Conference London, 38 Regent on the River
William Morris Way London SW6 2UT, United Kingdom
Tel: +44 (0)79 7317 3478  Fax: +44 (0)20 7491 0410
Emails :