John G Ionescu PhD
Prof. Ionescu is Scientific Director and founder
of the Special Clinic Neukirchen, Bio-Data and Energy Cosmetic companies,
located in 93453 Neukirchen, Germany.
After graduation in biochemistry and immunology at the University of
Bucharest, 1976 and a scientific fellowship in Montreal, Canada, he
wandered to West-Germany and established there since 1980.
He received his PhD in medical biochemistry 1983 from the University
of Saarbrücken, Germany, and directed until 1985 the research programme
of a dermatological clinic in Aschaffenburg. Main research areas included
the atopic diseases, psoriasis, arthritis and the MCS-syndrome.
Prof. Ionescu founded 1986 in Bavaria the Special Clinic Neukirchen
for the treatment of allergic, skin and environmental diseases according
to the principles of the nutritional and environmental medicine. The
160 bed facility is fully integrated in the official hospital system
and the treatment fees are reimbursed by all German and Austrian health
The original diagnostic and therapeutic approaches of his cortisone-,
cytostatic- and radiation-free concept have been reported in more than
140 scientific publications in Germany, Europe and USA. Current work
involves the investigation of biological redox systems and free radical
reactions in skin, environmental and cancer patients. His research results
are subjects of new methods for the rapid free radical and redox potential
assessment in human blood samples, new dermatological formulations for
the diseased and aging skin, patented anti-cancer drugs and original
integrative protocols for the treatment of MCS, CFS and chronic dermatoses.
Prof. Ionescu is member of the European Academy for Allergology and
Clinical Immunology, of the British Society for Allergy and Environmental
Medicine and of the American Academy of Environmental Medicine. As Scientific
Director he is also active in the Board of the International Oxidative
Medical Association (USA) and of the NRW Multiple Chemical Sensitivity
Since August 1998 he was nominated as Professor for Clinical Biochemistry
and Oxidology at the Capital University of Integrative Medicine, Washington,
D.C. (USA). Prof. Ionescu is also member of the Editorial Board of the
Journal of the Capital University of Integrative Medicine.
New Strategies to Slow Down the Photoaging of Human Skin
The photoaging process
of the skin in the presence of natural sunlight or artificial UV-sources
happens continuously and leads in time to dryness, deep wrinkles,
sagging, lost of elasticity, mottled pigmentation and skin telangiectasia.
Typical biomarkers include a strong generation of free radicals,
lipid peroxidation, collagenase activation, glycation / oxidation
of proteins (AGE products), activation of p53 transcription factors,
low DNA repair capacity and cumulative DNA mutations.
Clinically, the adverse effects of natural sunlight and other UV-sources
on normal human skin may vary from sunburn with erythema, oedema
and DNA damage (12-24 hrs. after UV-exposure) to polymorphic light
reaction (eczema solare), solar actinic elastosis and actinic hyperkeratosis
(as common precancerous condition), up to different skin cancer forms
like basal cell carcinoma (BCC), squamous cell carcinoma (SCC) or malignant
The study of the lipid, protein and DNA oxidative damage triggered
by the free radical attack and subsequent sunlight exposure has conducted
to appropriate strategies to slow down or block these reactions making
possible the design of innovative skin care formulations.
In this respect, a new German photoaging defence formula (Solaris®)
combines for the first time the double UVA + UVB protection (SPF 25)
with melanin promoting aminoacids directly enhancing the natural tanning
process. Free radical and metal blocking agents like Vit. E, carrot
oil and EDTA, respectively, are preventing the sun exposure side-effects
together with immune stimulating plant extracts (b-glucans) with anti-herpes
To slow down the photoaging related wrinkle formation efficiently,
a new collagen synthase stimulating formula (Energo® Repair Complex)
provides a synergistic anti-aging combination of UV-light blockers,
free radical quenchers (Vit. E, Coenzyme Q10) and collagen/ elastin
synthesis promoters like hydroxyprolin and soy bioflavonoids. The active
ingredients are incorporated in liposomes containing skin identical
phospholipids and ceramides by means of the patented DMS® nanoparticle
technology. A rapid uptake in the epidermis cells is thus granted.
The use of the described hypoallergenic topical products results in
a significant improvement of the skin structure and appearance within
30 days, as documented with the standardized Surface Evaluation of
Living Skin (SELS) methodology.
Goals & Objectives
- Understanding the typical free radical related side-effects of
natural and artificial UV-light exposure on human skin
Identifying the free radical induced lipid peroxidation and collagenase
activation leading to collagen breakdown and wrinkle formation
- Discussing the role of UV-induced metal mobilisation (Fe, Cu) in
the photoaging process and appropriate interventions to slow down
- Describing innovative procedures and formulas to counteract the
described photoaging mechanisms and monitoring the therapy results
by means of the standardized SELS methodology